Recently, the phrase "at the end of the day" has really been bothering me. I don't think I ever paid it much mind until a few months ago, when someone was continuing to use it in the context of "Well, I know it's not your responsibility, but at the end of the day, it's got to get done."
Now I hear it all the time, and I can't help counting the times I hear it in a given presentation. I guess I just have to work on getting over it. Perhaps, like getting a song stuck in your head, I just need to find something to replace it as my "most irritating" phrase. Maybe a good candidate would be "when the money hits the fan". No - I've just heard that once and mostly thought it was amusing.